TLDR: We study proteases in the context of myogenesis and myopathies. Our favorite approach is chemo-proteomics.

Our overarching goal is to understand how proteolytic switches are designed and actuated to induce rapid changes in cell morphology, behavior, and identity. We combine chemical biology, proteomics/genomics, and zebrafish models. We are also interested in the aberrant (de)activation of developmental proteases in aging and age-related diseases. Ultimately, we want to identify a combination of protease inhibitors/activators that can modulate cell fate or cure diseases – i.e., Yamanaka factors in the form of protease-activity modulating chemicals.